Can sildenafil reduce the risk of developing Alzheimer's disease?
Gradually forgetting everything and becoming unable to take care of oneself in life... Alzheimer's disease (senile dementia) troubles many middle-aged and elderly people, and there is no effective way to cure it. Scientists have been searching for ways to intervene and treat Alzheimer's disease.
On December 6, 2021, a study published in the journal Nature Aging found a significant correlation between the use of sildenafil and a 69% reduction in the risk of developing Alzheimer's disease, bringing new hope for the prevention and treatment of Alzheimer's disease!
Sildenafil is well-known for its use in improving male erectile dysfunction. This study developed a drug reuse method for Alzheimer's disease based on the "endophenotypic disease module". Among more than 1600 existing drugs approved by the US Food and Drug Administration (FDA), it began to search for those that could effectively treat Alzheimer's disease and ultimately targeted the highest scoring drug - sildenafil.
"Sildenafil has been shown to significantly improve cognition and memory in preclinical models, making it the best candidate drug," said Cheng Feixiong, a PhD and Chinese American scientist from the Cleveland Clinic Institute of Genomics who participated in the study
Although the results of this study indicate that people who take sildenafil have a lower risk of developing Alzheimer's disease, further research is still needed to prove it.
On December 6, 2021, a study published in the journal Nature Aging found a significant correlation between the use of sildenafil and a 69% reduction in the risk of developing Alzheimer's disease, bringing new hope for the prevention and treatment of Alzheimer's disease!
Sildenafil is well-known for its use in improving male erectile dysfunction. This study developed a drug reuse method for Alzheimer's disease based on the "endophenotypic disease module". Among more than 1600 existing drugs approved by the US Food and Drug Administration (FDA), it began to search for those that could effectively treat Alzheimer's disease and ultimately targeted the highest scoring drug - sildenafil.
"Sildenafil has been shown to significantly improve cognition and memory in preclinical models, making it the best candidate drug," said Cheng Feixiong, a PhD and Chinese American scientist from the Cleveland Clinic Institute of Genomics who participated in the study
Although the results of this study indicate that people who take sildenafil have a lower risk of developing Alzheimer's disease, further research is still needed to prove it.
