What male medications are more significant in prolonging sexual intercourse time?

1. PDE5 inhibitors (such as sildenafil, tadalafil, etc.): These drugs are mainly used to treat erectile dysfunction, but they may also indirectly prolong ejaculation time. They help enhance erection by increasing blood flow into the penis and may delay ejaculation to some extent.

2. 5-hydroxytryptamine reuptake inhibitors (SSRIs): These drugs were originally used to treat symptoms such as depression and anxiety, but some of them, such as dapoxetine, have also been found to prolong ejaculation time.