Which drugs have a significant effect on prolonging ejaculation time?

1. 5-hydroxytryptamine reuptake inhibitors: These drugs were originally used to treat depressive states, but in recent years, there have also been on-demand medications taken before sexual activity, such as dapoxetine, which performs well in blocking nerve conduction and preventing sexual stimulation from quickly spreading throughout the body, thereby prolonging ejaculation time.

Drugs that improve erectile function, such as tadalafil and sildenafil, may indirectly prolong ejaculation time due to their ability to improve erection.