Why can Priligy prolong sexual activity time?

Clinical trials have shown that the delayed effect of Priligy is about 2.5-3 times, and it is best to take it 1.5 hours before sexual activity.

Priligy, chemical name: dapoxetine hydrochloride, is a drug developed for premature ejaculation (PE) and has been approved by the National Food and Drug Administration (CFDA) for the treatment of premature ejaculation (PE) indications. The component of Priligy is a serotonin reuptake inhibitor, which can increase the concentration of serotonin in the brain.

The neural mechanism of premature ejaculation is that due to the low concentration of serotonin in the brain, the mechanism of inhibiting ejaculation in the brain is weakened, resulting in an increase in the brain's sensitivity to sexual stimuli and a decrease in ejaculation threshold.

The ingredients of these drugs are all the same, they are all serotonin reuptake inhibitors, and their mechanism of action is to temporarily increase the concentration of serotonin in the brain.

5-hydroxytryptamine and dopamine have a balance mechanism in the brain, where one goes against the other. When the concentration of 5-hydroxytryptamine is low, the concentration of dopamine is relatively high, making it easy for you to become particularly excited!

Due to the low concentration of serotonin, the mechanism of inhibiting ejaculation in the brain weakens and the mechanism of promoting ejaculation strengthens. This balance of controlling ejaculation is disrupted, and the ejaculatory reflex becomes more sensitive, making it difficult to control ejaculation.

Why does such a difference occur? There are congenital genetic factors as well as acquired cognitive behavior and ejaculation habits.

In fact, whether it is congenital or acquired factors that cause the central nervous system to become overly sensitive, premature ejaculation desensitization training can gradually change the balance mechanism in the brain, making ejaculation gradually controllable, and behavior can change the brain.

In 1956, James Semans proposed a treatment method for premature ejaculation called stop start, which can increase the stimulation threshold required for ejaculation and eliminate the abnormal relationship between sexual stimulation and sexual response.

The "Squeezing Technique" and Sexuality Concentration Training Method, founded by sexologists Masters Masters and Johnson in the 1970s, are a set of psychological and behavioral methods for learning sex with partners. Statistical data shows that after 1-3 months of training, 95.1% of men are able to overcome the problem of premature ejaculation.

These psychological and behavioral therapies can all improve the problem of premature ejaculation to a certain extent. Of course, this is a relatively slow process that requires you to patiently practice. Generally, three months of continuous training will have initial results, and premature ejaculation problems will be significantly improved.