[安博诺] 厄贝沙坦氢氯噻嗪片 0.15g:12.5mg*28片/盒

Basic Information3

• Trade Name：Aprovel
• Generic Name：Irbesartan and Hydrochlorothiazide Tablets
• Manufacturer：Sanofi Winthrop Industrie
• Approval Number：国药准字 HJ20140194 (HJ20140194 in Chinese Pharmacopoeia)
• Specification：0.15g:12.5mg×28 tablets/box
• Dosage Form：Film-coated tablets

Indications

Pharmacological Action

• Irbesartan：It is an angiotensin II receptor antagonist that blocks the binding of angiotensin II to the angiotensin II type 1 receptor, thereby relaxing blood vessels and reducing blood pressure.
• Hydrochlorothiazide：It is a diuretic that acts on the distal convoluted tubule of the kidney to inhibit the reabsorption of sodium and chloride ions, increasing urine output and reducing blood volume, thus achieving the effect of reducing blood pressure. The combination of the two has a synergistic antihypertensive effect.

Usage and Dosage

Adverse Reactions

• Common ones：Dizziness, nausea/vomiting, fatigue, increased BUN, creatinine and creatine kinase.
• Less Common ones：Postural dizziness, limb distal edema, muscle/bone pain, urinary abnormalities, changes in libido, sexual dysfunction.
• Rare ones：Angioedema, rash, pruritus and other hypersensitivity reactions, taste loss, indigestion, joint pain, myalgia, renal function impairment.

Contraindications

• Hypersensitivity to the active ingredients of this product or any excipient ingredients, or hypersensitivity to other sulfonamide derivatives (hydrochlorothiazide is a sulfonamide derivative).
• Pregnant women.
• Severe renal impairment (creatinine clearance rate <30ml/min).
• Refractory hypokalemia, hypercalcemia.
• Severe liver failure, biliary cirrhosis and cholestasis.

Precautions

• For patients with severe sodium and/or volume depletion, correct the condition before starting treatment.
• Use with caution in patients with renal artery stenosis.
• For patients with impaired renal function, serum potassium, creatinine and uric acid should be monitored regularly.
• In patients with liver function impairment, thiazide diuretics should be used with caution.
• This product may cause positive results in anti-doping tests.